Hydrochloric Acid → HCID 66597073, compound

HRID 1518620Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH2:24][CH2:25][C:26]([O:28]C(C)(C)C)=[O:27])[CH:15]=[CH:16][C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:10])[CH2:4][CH2:3]1.[ClH:33]>O1CCOCC1>[ClH:33].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([O:8][C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])[CH:15]=[CH:16][C:17]=2[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:10])[CH2:6][CH2:7]1

Participants

Conditions

Temperature: 70 °C

Procedure

To tert-butyl 3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate (5.08 g, 11.6 mmol) was added a 4M solution of hydrochloric acid in dioxane (70 mL) and the mixture was stirred at 70° C. for 2 hours. The reaction solution was concentrated under reduced pressure to obtain 3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate hydrochloride (5.49 g).

Workup

concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record: ord-61c1f225522147deb20973421acd404a
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09072734B2

Reaction notes

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