反应详情

温度

0 °C

Oxalyl chloride (0.39 g, 0.26 ml, 3.1 mmol) was added drop wise at 0° C. to a solution of 5-(4-chlorophenyl)-4-((dimethylamino)methyl)-3-(4sulfamoylphenyl)thiophene-2-carboxylic acid (compound 35d, 0.7 g, 1.55 mmol) in a mixture of dichloromethane (25 ml) and DMF (0.27 g, 0.24 ml, 3.10 mmol). The mixture so obtained was allowed to come at room temperature and stirred for 1.5 hr under a nitrogen atmosphere. The progress of the reaction was monitored by TLC. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was dissolved in dry dichloromethane (25 ml), cooled to 0° C. and to this was added triethylamine (0.94 g, 1.3 ml, 9.31 mmol) followed by the addition of N,O-dimethylhydroxylamine hydrochloride (0.3 g, 3.1 mmol) under stirring. The reaction mixture was then stirred at room temperature for 2 hr. The progress of the reaction was monitored by TLC. The reaction mixture was then diluted with DCM (25 ml) and washed with water (2×25 ml), the organic layer so obtained was dried over anhydrous sodium sulphate, and concentrated under reduced pressure to obtain a crude product. The crude product so obtained was purified by column chromatography over silica gel (100-200 mesh) using 6% methanol in DCM as an eluent to obtain the title compound (0.45 g, 52.81%).

1. customThe mixture so obtained
2. customto come at room temperature
3. concentrationThe reaction mixture was then concentrated under reduced pressure
4. customThe residue so obtained
5. stirringunder stirring
6. stirringThe reaction mixture was then stirred at room temperature for 2 hr
7. washwashed with water (2×25 ml)
8. customthe organic layer so obtained
9. dry with materialwas dried over anhydrous sodium sulphate
10. concentrationconcentrated under reduced pressure
11. customto obtain a crude product
12. customThe crude product so obtained
13. customwas purified by column chromatography over silica gel (100-200 mesh)