Hydrochloric Acid → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

HRID 1518812Notes

Reaction equation

HRID 1518812 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Cl>ClCCl>[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

Product 1

HCID 225621451-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 173A (52.57 g) in dichloromethane (900 mL) was treated with 4M HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

Workup

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-2d8dc1bedde942548875e25f131d7407
Source dataset
uspto-grants-2015_07
Patent number
US09072748B2

Reaction notes

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