反应详情

温度

90 °C

A mixture of EXAMPLE 173B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 173B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide, heated at 90° C. for 16 hours, cooled and concentrated. 10% methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and the mixture was filtered.

1. dissolutioncompletely dissolved
2. temperaturecooled
3. concentrationconcentrated
4. addition10% methanol in dichloromethane was added
5. filtrationthe mixture was filtered