4-Methoxybenzylamine → 4-methoxycyclohexanemethan amine

HRID 1518846Notes

Reaction equation

HRID 1518846 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1>C(O)C>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH2:9][NH2:10])[CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 754524-Methoxybenzylamine

Product 1

HCID 552816864-methoxycyclohexanemethan amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(4-Methoxyphenyl)methanamine (1 g) in ethanol (10 ml) was treated with 5% dry Rh—Al2O3 (0.5 g) under H2 (500 psi) at 60° C. for 6 hours and then at 125° C. for 26 hours. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

Workup

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-fa5a331108c04b3a90edfe5bfd966465
Source dataset
uspto-grants-2015_07
Patent number
US09072748B2

Reaction notes

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