Diisopropylethylamine → 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide

HRID 1518854노트

반응식

HRID 1518854 반응식
[C:1]([C:3]1[CH:4]=[C:5]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1F)#[N:2].[O:14]1[CH2:19][CH2:18][CH:17]([CH2:20][NH2:21])[CH2:16][CH2:15]1.C(N(CC)C(C)C)(C)C>O1CCCC1.C(OCC)(=O)C>[C:1]([C:3]1[CH:4]=[C:5]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:6]=[CH:7][C:8]=1[NH:21][CH2:20][CH:17]1[CH2:18][CH2:19][O:14][CH2:15][CH2:16]1)#[N:2]

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 27732104-AminomethyltetrahydropyranHCID 251398973-Cyano-4-fluorobenzene-1-sulfonamide

생성물 1

HCID 671265013-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

3-Cyano-4-fluorobenzenesulfonamide (500 mg), (tetrahydropyran-4-yl)methylamine (288 mg), and N,N-diisopropylethylamine (1.3 mL) were heated at 80° C. in tetrahydrofuran (15 mL) overnight. The mixture was diluted with ethyl acetate, washed with NaHCO3 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.

후처리

  1. washwashed with NaHCO3 solution and brine
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe product was triturated from ethyl acetate

출처 및 근거

ORD 기록
ord-07f62591d2344b1eb2a01b6b890e4f51
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09072748B2

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