3-Chloro-1-propanol → HCID 118202508, compound

HRID 1518909Notes

Reaction equation

HRID 1518909 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[C:8](=[N:10]/[OH:11])/[CH3:9].Cl[CH2:13][CH2:14][CH2:15][OH:16]>>[OH:16][CH2:15][CH2:14][CH2:13][O:11]/[N:10]=[C:8](/[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH2:1])\[CH3:9]

Participants

3

Reactant 2

HCID 123133-Chloro-1-propanolHCID 5712522HCID 5712522, compound

Product 1

HCID 118202508HCID 118202508, compound

Procedure

In Scheme 3, Compound (α1) is reacted with hydroxylamine hydrochloride to obtain (E)-1-(2-aminophenyl)ethanone oxime (Compound (a4)). Compound (a4) is reacted with 3-chloropropan-1-ol to obtain (E)-1-(2-aminophenyl)ethanone O-3-hydroxypropyl oxime (Compound (a5)). Compound (a5) is then reacted with p-pivaloyloxybenzenesulfonyl chloride to obtain the compound of formula (I). The following Compound (7) in Preparation Examples 6 was prepared using Scheme 3.

Sources & evidence

ORD record
ord-4c94e8930d1f488183ff77d6d88f019e
Source dataset
uspto-grants-2015_07
Patent number
US09073833B1

Reaction notes

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