Potassium Carbonate → HCID 118202508, compound

HRID 1518912Notes

Reaction equation

HRID 1518912 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1/[C:8](=[N:10]/[OH:11])/[CH3:9].C([O-])([O-])=O.[K+].[K+].Cl[CH2:19][CH2:20][CH2:21][OH:22]>C(#N)C>[OH:22][CH2:21][CH2:20][CH2:19][O:11]/[N:10]=[C:8](/[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH2:1])\[CH3:9]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 123133-Chloro-1-propanolHCID 5712522HCID 5712522, compound

Product 1

HCID 118202508HCID 118202508, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(E)-1-(2-aminophenyl)ethanone oxime (0.2 mmol) was added into anhydrous acetonitrile (MeCN) (10 mL), followed by adding K2CO3 (1.1 equivalent weights) and 3-chloropropan-1-ol (5 equivalent weights) therein to obtain a mixture. The mixture was heated under reflux for 36 hours and was purified using a silica gel column (n-hexane/acetone=2:1), thereby obtaining (E)-1-(2-aminophenyl)ethanone O-3-hydroxypropyl oxime (168 mg, yield 81%).

Workup

  1. customto obtain a mixture
  2. temperatureThe mixture was heated
  3. temperatureunder reflux for 36 hours
  4. customwas purified

Sources & evidence

ORD record
ord-2fb6b3bd191f450fad1f3883dfa04338
Source dataset
uspto-grants-2015_07
Patent number
US09073833B1

Reaction notes

Loading…