反应详情

methyl-2-(4-acetylphenylsulfonamido)-2-methylpropanoate (2.55 g, 8.52 mmol) was charged, and dissolved through addition of THF (20 ml), and methanol (20 ml). LiOH.H2O dissolved in H2O (10 ml) was added thereto, followed by stirring for 12 hours at room temperature. After stirring for 12 hours, the resultant solution was vacuum-evaporated, acidified with 2N—HCl to pH 2-3, and extracted with EA (×2). The organic layer was dried with MgSO4, and filtered. Through vacuum distillation, the solvent was removed so as to obtain 2-(4-acetylphenylsulfonamido)-2-methylpropionic acid (2.38 g, 8.35 mmol, 98%).

1. additionwas added
2. stirringAfter stirring for 12 hours
3. customthe resultant solution was vacuum-evaporated
4. extractionextracted with EA (×2)
5. dry with materialThe organic layer was dried with MgSO4
6. filtrationfiltered
7. distillationThrough vacuum distillation
8. customthe solvent was removed so as