HCID 14343212, compound → HCID 12637757, compound

HRID 1519182Notes

Reaction equation

HRID 1519182 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1>[Pd].CO>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1

Participants

4

Reactant 1

HCID 14343212HCID 14343212, compound

Product 1

HCID 12637757HCID 12637757, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-methyl-2-phenylethynyl-pyridine (18.2 g) and 10% palladium on carbon (2.0 g) in methanol (300 mL) is stirred under hydrogen atmosphere (50 psi) at ambient temperature until the triple bond is completely reduced (20 h). The mixture is filtrered and the solvent is removed under reduced pressure.

Workup

  1. custom(20 h)
  2. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-1623e21499c743de8240c667b9214958
Source dataset
uspto-grants-2015_07
Patent number
US09073870B2

Reaction notes

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