Methylparaben → HCID 71184062, compound

HRID 1519242Notes

Reaction equation

HRID 1519242 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[O:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[N:11][C:10]=2[CH2:21][OH:22])=[N:6][CH:7]=1.[C:23]([C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][CH:28]=1)([O:25][CH3:26])=[O:24]>>[CH3:26][O:25][C:23](=[O:24])[C:27]1[CH:32]=[CH:31][C:30]([O:22][CH2:21][C:10]2[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[O:13][C:9]=2[S:8][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 7456MethylparabenHCID 71184222HCID 71184222, compound

Product 1

HCID 71184062HCID 71184062, compound

Procedure

Prepared from {5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}methanol (INTERMEDIATE B1.1) and 4-carbomethoxyphenol using a similar procedure as described in the preparation of example B2.1. MS: M+H=471.

Workup

  1. customas described in the preparation of example B2.1

Sources & evidence

ORD record
ord-c98170a2110e491181e3db83670b9844
Source dataset
uspto-grants-2015_07
Patent number
US09073879B2

Reaction notes

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