Methylamine → HCID 54575706, compound

HRID 1519250Notes

Reaction equation

HRID 1519250 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[O:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[N:11][C:10]=2[CH:21]([O:23][C:24]2[CH:33]=[CH:32][C:27]([C:28](OC)=[O:29])=[CH:26][CH:25]=2)[CH3:22])=[N:6][CH:7]=1.[CH3:34][NH2:35]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][C:9]2[O:13][C:12]([C:14]3[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=3)=[N:11][C:10]=2[CH:21]([O:23][C:24]2[CH:25]=[CH:26][C:27]([C:28]([NH:35][CH3:34])=[O:29])=[CH:32][CH:33]=2)[CH3:22])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 54575705HCID 54575705, compound

Product 1

HCID 54575706HCID 54575706, compound

Procedure

Prepared from hydrolysis of methyl 4-(1-{5-[(5-chloropyridin-2-yl)sulfanyl]-2-(4-fluorophenyl)-1,3-oxazol-4-yl}ethoxy)benzoate (EXAMPLE 137.1) followed by methylamine coupling, using a similar procedure as described in the preparation of examples 132.11.1 and B2.11.2. MS: M+H=484.

Workup

  1. customas described in the preparation of examples 132.11.1 and B2.11.2

Sources & evidence

ORD record
ord-4a44f3fd807c46aa82338361442828a2
Source dataset
uspto-grants-2015_07
Patent number
US09073879B2

Reaction notes

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