反应详情

温度

70 °C

A mixture of 2-bromo-5-carbamothioylbenzoic acid methyl ester (which may be prepared as described for Intermediate 5; 13.7 g, 50 mmol) and 2-bromo-3′,4′-dichloroacetophenone (available from Aldrich Chemical Company, Inc.; 13.5 g, 50.5 mmol) in EtOH (200 mL) was heated at 70° C. overnight. The solid was filtered off to give 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (18.14 g, 82%).

1. filtrationThe solid was filtered off