Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1519256생성일: 2026년 10월 25일
2-Bromo-1-(3,4-dichlorophenyl)ethanone → Methyl 2-bromo-5-(4-(3,4-dichlorophenyl)thiazol-2-yl)benzoate
https://huagongshe.com/reaction/1519256
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Bromo-1-(3,4-dichlorophenyl)ethanone | HCID 244751 | — |
| 반응물 | Methyl 2-bromo-5-carbamothioylbenzoate | HCID 86679834 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Methyl 2-bromo-5-(4-(3,4-dichlorophenyl)thiazol-2-yl)benzoate | HCID 86679833 | 82% |
반응 단계
A mixture of 2-bromo-5-carbamothioylbenzoic acid methyl ester (which may be prepared as described for Intermediate 5; 13.7 g, 50 mmol) and 2-bromo-3′,4′-dichloroacetophenone (available from Aldrich Chemical Company, Inc.; 13.5 g, 50.5 mmol) in EtOH (200 mL) was heated at 70° C. overnight. The solid was filtered off to give 2-bromo-5-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-benzoic acid methyl ester (18.14 g, 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09073881B2 |
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| 출처 데이터셋 | uspto-grants-2015_07 |
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| ORD ID | ord-df9fa1c9adb640a9bef6950517d9a483 |
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| 출처 메모 | uspto-grants-2015_07 |
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