反应详情

2′-Nitro-4-[4-(3-trifluoromethyl-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid (53 mg, 18%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 3-(trifluoromethyl)phenacyl bromide (available from Oakwood Products, Inc.) using the procedure described for the preparation of Example 18 except that the entire 4 mL of water was added at the beginning of the hydrolysis step rather than being added in two portions. 1H NMR (300 MHz, DMSO-d6) δ 13.13 (br s, 1H), 8.53-8.58 (m, 2H), 8.38 (s, 2H), 8.27-8.31 (m, 1H), 8.13-8.18 (m, 1H), 7.63-7.82 (m, 4H), 7.41-7.49 (m, 2H).

1. additionwas added at the beginning of the hydrolysis step rather
2. additionthan being added in two portions