HCID 86694441, compound → HCID 68071327, compound

HRID 1519501Notes

Reaction equation

HRID 1519501 reaction equation
[CH3:1][C@H:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][CH2:13][N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[CH:9]=2)[C:4](=[O:27])[O:3]1>Cl>[CH3:1][C@H:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[CH:9]=2)[C:4](=[O:27])[O:3]1

Participants

3

Reactant 1

HCID 86694441HCID 86694441, compound

Product 1

HCID 68071327HCID 68071327, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of tert-butyl 4-{2-[(3S)-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-6-yl]ethyl}piperazine-1-carboxylate in 4N HCl indioxane was stirred at room temp for 4 hours and the excess solvent removed. The residue was partitioned between 10% IPA/Chloroform and 1N NaOH. The organic layer was dried over magnesium sulfate, filtered and concentrated. The free amine was used without further purification.

Workup

  1. customthe excess solvent removed
  2. customThe residue was partitioned between 10% IPA/Chloroform and 1N NaOH
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe free amine was used without further purification

Sources & evidence

ORD record
ord-d6b191636aec4221ba059e53515d713f
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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