Hydrochloric Acid → HCID 67516643, compound

HRID 1519506Notes

Reaction equation

HRID 1519506 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)[CH2:6]2)#[N:2].[ClH:25]>O1CCOCC1>[Cl-:25].[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([N:12]1[CH2:17][CH2:16][NH2+:15][CH2:14][CH2:13]1)[CH2:6]2)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67517763tert-butyl 4-(5-cyano-2,3-dihydro-1H-inden-2-yl)piperazine-1-carboxylate

Product 1

HCID 67516643HCID 67516643, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a 4 mL reaction vial, was added tert-butyl 4-(5-cyano-2,3-dihydro-1H-inden-2-yl)piperazine-1-carboxylate. To above vial was added 4 N HCl in dioxane (1 mL), let stirred at RT for 2 hr. The reaction mixture was concentrated to give the desired product. LC-MS (IE, m/z): 228.3 [M+1]+.

Workup

  1. customIn a 4 mL reaction vial
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d9824cb1ca0249c0b82e59c4ea933bea
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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