Hydrochloric Acid → 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride

HRID 1519514Notes

Reaction equation

HRID 1519514 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:26][CH2:25][C:24]3[C:16](=[CH:17][C:18]4[C:19]([CH:23]=3)=[N:20][O:21][N:22]=4)[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[N:11]1([CH:14]2[CH2:26][CH2:25][C:24]3[C:16](=[CH:17][C:18]4[C:19]([CH:23]=3)=[N:20][O:21][N:22]=4)[CH2:15]2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86694448tert-Butyl 4-(5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazol-6-yl)piperazine-1-carboxylate

Product 1

HCID 866944496-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a flask charged with tert-Butyl-4-(5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazol-6-yl)piperazine-1-carboxylate (50 mg, 0.14 mmol) was added 4N HCl in dioxane (1 mL). The mixture was allowed to stir for 30 minutes at RT. LC showed complete reaction. The solvent was removed under reduced pressure, and the resulting 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride was used without further purification.

Workup

  1. customreaction
  2. customThe solvent was removed under reduced pressure
  3. customthe resulting 6-Piperazin-1-yl-5,6,7,8-tetrahydronaphtho[2,3-c][1,2,5]oxadiazole hydrochloride was used without further purification

Sources & evidence

ORD record
ord-c5ac44214e3942288e6cad80ebae6cd7
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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