Trifluoroacetic acid → HCID 86694466, compound

HRID 1519566Notes

Reaction equation

HRID 1519566 reaction equation
C([O:5][CH2:6][CH:7]1[CH2:12][N:11]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9][N:8]1[CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[CH:28][CH:27]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N+:32]([C:29]1[CH:28]=[CH:27][C:26]([CH2:25][CH2:24][N:8]2[CH2:9][CH2:10][N:11]([CH2:13][CH2:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)[CH2:12][CH:7]2[CH2:6][OH:5])=[CH:31][CH:30]=1)([O-:34])=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86694467HCID 86694467, compound

Product 1

HCID 86694466HCID 86694466, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 2-(tert-butoxymethyl)-1,4-bis[2-(4-nitrophenyl)ethyl]piperazine (30 mg) in DCM (2 mL) was added TFA (2 mL). The reaction was allowed to stir at 25° C. for 2 hours. LC showed complete removal of the tert-butyl group. The solvents were removed under reduced pressure, and the residue was collected without further purification. LC-MS (IE, m/z): 415 [M+1]+. (0.26 μM)

Workup

  1. customremoval of the tert-butyl group
  2. customThe solvents were removed under reduced pressure
  3. customthe residue was collected without further purification

Sources & evidence

ORD record
ord-c66b211330ff4579968550fc6d0a59a6
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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