Allyltributylstannane → 4-Allyl-2,6-difluorobenzonitrile

Participants

Reaction Steps

A mixture of 4-bromo-2,6-difluorobenzonitrile (2.0 g, 9.2 mmol), allyl-tributyl-stannane (3.65 g, 11.0 mmol), LiCl (1.17 mg, 28 mmol) and Pd(PPh)4 (0.2 g) in 70 mL of anhydrous toluene was refluxed under N2 overnight. Checked the reaction with TLC and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the product 4-allyl-2,6-difluorobenzonitrile. MS m/z: 180 (M+1)+.

Provenance & Evidence