反应详情

A mixture of 4-bromo-2,6-difluorobenzonitrile (2.0 g, 9.2 mmol), allyl-tributyl-stannane (3.65 g, 11.0 mmol), LiCl (1.17 mg, 28 mmol) and Pd(PPh)4 (0.2 g) in 70 mL of anhydrous toluene was refluxed under N2 overnight. Checked the reaction with TLC and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the product 4-allyl-2,6-difluorobenzonitrile. MS m/z: 180 (M+1)+.

1. temperaturewas refluxed under N2 overnight
2. customChecked the reaction with TLC
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography