反应详情

To a solution of 4-allyl-2,6-difluorobenzonitrile (1.7 g, 9.2 mmol) in 30 mL of methanol and 10 mL of water was added OsO4 (210 mg) and NMO (3.11 g, 23 mmol), and the mixture was stirred at ambient temperature overnight. Remove the methanol under reduced pressure, the residue was dissolved in EtOAc, washed with brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by fast column chromatograph to give 4-(2,3-dihydroxypropyl)-2,6-difluorobenzonitrile. MS m/z: 214 (M+1)+.

1. customRemove the methanol under reduced pressure
2. dissolutionthe residue was dissolved in EtOAc
3. washwashed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by fast column chromatograph