5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → 5-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one

HRID 1519607Notes

Reaction equation

HRID 1519607 reaction equation
Cl.[N:2]1([CH2:8][CH2:9][C:10]2[CH:19]=[CH:18][C:13]3[C:14](=[O:17])[O:15][CH2:16][C:12]=3[CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N:20]1([C:25]2[N:30]=[CH:29][C:28]([CH2:31][CH:32]=O)=[CH:27][CH:26]=2)[CH:24]=[N:23][N:22]=[N:21]1>>[N:20]1([C:25]2[N:30]=[CH:29][C:28]([CH2:31][CH2:32][N:5]3[CH2:6][CH2:7][N:2]([CH2:8][CH2:9][C:10]4[CH:11]=[C:12]5[C:13](=[CH:18][CH:19]=4)[C:14](=[O:17])[O:15][CH2:16]5)[CH2:3][CH2:4]3)=[CH:27][CH:26]=2)[CH:24]=[N:23][N:22]=[N:21]1

Participants

3

Reactant 2

HCID 666467325-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochlorideHCID 772307002-(6-(1H-tetrazol-1-yl)pyridin-3-yl)acetaldehyde

Product 1

HCID 680718805-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one

Procedure

5-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one was prepared in a similar fashion to that described for the synthesis of Example 38 starting from 5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride and [6-(1H-tetrazol-1-yl)pyridin-3-yl]acetaldehyde. LC-MS (IE, m/z): 392.0 [(M+1)+−28]. (0.91 μM)

Sources & evidence

ORD record
ord-0feae42bc37146579eaae43ee91f8ebc
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

Loading…