HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride → 5-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(2-piperazin-1-ylethyl)-2-benzofuran-1(3H)-one hydrochloride | HCID 66646732 | — |
| Reactant | 2-(6-(1H-tetrazol-1-yl)pyridin-3-yl)acetaldehyde | HCID 77230700 | — |
| Product | 5-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one | HCID 68071880 | — |
Reaction Steps
5-[2-[4-[2-[6-(Tetrazol-1-yl)-3-pyridyl]ethyl]piperazin-1-yl]ethyl]-3H-isobenzofuran-1-one was prepared in a similar fashion to that described for the synthesis of Example 38 starting from 5-[2-(piperazin-1-yl)ethyl]-2-benzofuran-1(3H)-one hydrochloride and [6-(1H-tetrazol-1-yl)pyridin-3-yl]acetaldehyde. LC-MS (IE, m/z): 392.0 [(M+1)+−28]. (0.91 μM)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073882B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-0feae42bc37146579eaae43ee91f8ebc |
| Source note | uspto-grants-2015_07 |