Hydrochloric Acid → HCID 69087509, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-3-(trifluoromethyl)piperazine-1-carboxylate (183 mg, 0.44 mmol) in 1,4-dioxane (2 ml) was added 4 N HCl in dioxane (1 mL) and the reaction stirred at room temperature for 12 h. LC-MS shows product formation. The reaction mixture was concentrated in vacuo and dried under high vacuum to provide 5-{2-[2-(trifluoromethyl)piperazin-1-yl]ethyl}-2-benzofuran-1(3H)-one which was used directly without further purification. LC-MS (IE, m/z): 194.2 [M+1]+.

Provenance & Evidence