Hydrochloric Acid → HCID 69087509, compound

HRID 1519616Notes

Reaction equation

HRID 1519616 reaction equation
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH:14]3[C:26]([F:29])([F:28])[F:27])=[CH:10][C:5]=2[CH2:4][O:3]1.Cl>O1CCOCC1>[F:29][C:26]([F:27])([F:28])[CH:14]1[CH2:15][NH:16][CH2:17][CH2:18][N:13]1[CH2:12][CH2:11][C:9]1[CH:8]=[CH:7][C:6]2[C:2](=[O:1])[O:3][CH2:4][C:5]=2[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86694484HCID 86694484, compound

Product 1

HCID 69087509HCID 69087509, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 4-[2-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)ethyl]-3-(trifluoromethyl)piperazine-1-carboxylate (183 mg, 0.44 mmol) in 1,4-dioxane (2 ml) was added 4 N HCl in dioxane (1 mL) and the reaction stirred at room temperature for 12 h. LC-MS shows product formation. The reaction mixture was concentrated in vacuo and dried under high vacuum to provide 5-{2-[2-(trifluoromethyl)piperazin-1-yl]ethyl}-2-benzofuran-1(3H)-one which was used directly without further purification. LC-MS (IE, m/z): 194.2 [M+1]+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-fe76e974483746409775311c06d02c48
Source dataset
uspto-grants-2015_07
Patent number
US09073882B2

Reaction notes

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