Trifluoroacetic acid → 7-Benzothiazoleacetic acid

HRID 1519753Notes

Reaction equation

HRID 1519753 reaction equation
Br[C:2]1[C:10]2[S:9][CH:8]=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:11]([OH:17])([C:13](F)(F)F)=[O:12]>>[S:9]1[C:10]2[C:2]([CH2:13][C:11]([OH:17])=[O:12])=[CH:3][CH:4]=[CH:5][C:6]=2[N:7]=[CH:8]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 115213507-Bromobenzothiazole

Product 1

HCID 687568187-Benzothiazoleacetic acid

Procedure

The title compound (20 mg) was prepared from 7-bromobenzo[d]thiazole according to protocol P. LCMS (0.05% TFA): [M+1]+ 194.1. 1H-NMR (CDCl3, 400MHz): δ9.05 (s, 1H), 8.10(d, 1H, J=6.8Hz), 7.53 (m, 1H), 7.39 (d, 1H, J=6.8Hz), 3.96(s, 2H).

Sources & evidence

ORD record
ord-aa41acc0cffc42a0b18540771aebc5bb
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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