2-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acid → Methyl 4-bromo-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate

HRID 1519769노트

반응식

HRID 1519769 반응식
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH2:12][C:13]([OH:15])=O.[NH2:16][C:17]1[S:18][CH:19]=[C:20]([Br:26])[C:21]=1[C:22]([O:24][CH3:25])=[O:23]>>[Br:26][C:20]1[C:21]([C:22]([O:24][CH3:25])=[O:23])=[C:17]([NH:16][C:13](=[O:15])[CH2:12][N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:10][CH2:11][C:2]2=[O:1])[S:18][CH:19]=1

참가 물질

3

반응물 2

HCID 167842212-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acidHCID 68754257Methyl 2-amino-4-bromothiophene-3-carboxylate

생성물 1

HCID 68782720Methyl 4-bromo-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate

실험 절차

The title compound was prepared from 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid (447 mg, 2.18 mmol) and methyl 2-amino-4-bromothiophene-3-carboxylate (516 mg, 2.18 mmol) according to protocol A. Retention time (min)=2.528, method [1], MS(ESI) 423.0 (M+H).

출처 및 근거

ORD 기록
ord-1400d3487e5a4e84a58ae37127f10bfa
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073891B2

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