Hydrochloric Acid → 2-(Quinoxalin-5-yl)acetic acid

HRID 1519773Notes

Reaction equation

HRID 1519773 reaction equation
[N:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1.Cl>CC(O)=O>[N:1]1[C:10]2[C:5](=[C:6]([CH2:11][C:12]([OH:14])=[O:13])[CH:7]=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68754230HCID 68754230, compound

Product 1

HCID 177818242-(Quinoxalin-5-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

To a stirring mixture of tert-butyl 2-(quinoxalin-5-yl)acetate (200 mg) in HOAc (5 mL) was added 6N HCl (5 mL). The reaction mixture was warmed to 80° C. for 2 h. The crude product mixture was concentrated under reduced pressure to give 2-(quinoxalin-5-yl)acetic acid, which was used in the next reaction without further purification. Method[1], MS(ESI) 189.0 [M+H], Retention time=0.722 min.

Workup

  1. concentrationThe crude product mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-73d8c187f3304c2193bbe5d5b8f9b86f
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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