Lithium hydroxide, monohydrate → 2-(6-Ethynyl-2-oxoquinolin-1(2H)-yl)acetic acid

HRID 1519888Notes

Reaction equation

HRID 1519888 reaction equation
[O:1]=[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]#[C:13][Si](C)(C)C)[CH:8]=2)[N:3]1[CH2:18][C:19]([O:21]C)=[O:20].O[Li].O>>[C:12]([C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]([CH2:18][C:19]([OH:21])=[O:20])[C:2](=[O:1])[CH:11]=[CH:10]2)#[CH:13]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 68756967Methyl 2-(2-oxo-6-((trimethylsilyl)ethynyl)quinolin-1(2H)-yl)acetate

Product 1

HCID 866494242-(6-Ethynyl-2-oxoquinolin-1(2H)-yl)acetic acid

Procedure

Methyl 2-(2-oxo-6-((trimethylsilyl)ethynyl)quinolin-1(2H)-yl)acetate (0.128 mmol) was subjected to the protocol in Example 1.53.4, except with LiOH.H2O instead of NaOH. Retention time (min)=1.435, method [1], MS(ESI) 228.1 (M+H).

Sources & evidence

ORD record
ord-3b3b058665884ae88bd93b95cf9e205a
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

Loading…