2-Chloro-3-nitrothiophene → HCID 68754289, compound

HRID 1519909Notes

Reaction equation

HRID 1519909 reaction equation
ClC1SC=CC=1[N+]([O-])=O.C([Sn](CCCC)(CCCC)C1SC=CN=1)CCC.[N+:28]([C:31]1[CH:35]=[CH:34][S:33][C:32]=1[C:36]1[S:37][CH:38]=[CH:39][N:40]=1)([O-:30])=[O:29]>>[N+:28]([C:31]1[CH:35]=[CH:34][S:33][C:32]=1[C:36]1[S:37][CH:38]=[CH:39][N:40]=1)([O-:30])=[O:29].[S:37]1[CH:38]=[CH:39][N:40]=[C:36]1[C:32]1[S:33][CH:34]=[CH:35][C:31]=1[NH2:28]

Participants

5

Reactant 3

HCID 2201862-Chloro-3-nitrothiopheneHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 68754289HCID 68754289, compound

Product 2

HCID 68754289HCID 68754289, compoundHCID 68754843HCID 68754843, compound

Procedure

2-(3-Nitrothiophen-2-yl)thiazole was synthesized from 2-chloro-3-nitrothiophene according to protocol E except that 2-(tributylstannyl)thiazole was used. Method[1], MS(ESI) 212.9 [M+H], Retention time=2.163 min. 2-(Thiazol-2-yl)thiophen-3-amine was synthesized from 2-(3-nitrothiophen-2-yl)thiazole according to protocol F. Method[1], MS(ESI) 183 [M+H], Retention time=1.718 min.

Sources & evidence

ORD record
ord-7bd1335ace894cdb8585f2686956c0a7
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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