反应详情

温度

60 °C

A 30 mL reaction vial was charged with 5-nitro-4-(thiazol-2-yl)thiophene-3-carbonitrile (180 mg, 0.76 mmol) and AcOH (3 mL). A spatula tip of iron dust was added and the reaction vial was heated to 60° C. for 20 min. The reaction mixture was cooled to 23° C. and partitioned between methylene chloride and sodium bicarbonate solution. The organic solution was dried over sodium sulfate and concentrated to give 5-amino-4-(thiazol-2-yl)thiophene-3-carbonitrile as a red solid. LCMS showed an m/z of 208.0 with a retention time of 2.016 min using method [1].

1. customA 30 mL reaction
2. customthe reaction
3. temperatureThe reaction mixture was cooled to 23° C.
4. custompartitioned between methylene chloride and sodium bicarbonate solution
5. dry with materialThe organic solution was dried over sodium sulfate
6. concentrationconcentrated