4-Iodophenylacetic acid → Methyl 2-(2-(4-iodophenyl)acetamido)-4-methylthiophene-3-carboxylate

HRID 1519949Notes

Reaction equation

HRID 1519949 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([CH3:22])[C:17]=1[C:18]([O:20][CH3:21])=[O:19]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH:12][C:13]2[S:14][CH:15]=[C:16]([CH3:22])[C:17]=2[C:18]([O:20][CH3:21])=[O:19])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1372144-Iodophenylacetic acidHCID 2759773Methyl 2-amino-4-methylthiophene-3-carboxylate

Product 1

HCID 68755598Methyl 2-(2-(4-iodophenyl)acetamido)-4-methylthiophene-3-carboxylateYield 87%

Procedure

The title compound was synthesized in 87% yield according to protocol A from 2-(4-iodophenyl)acetic acid and methyl 2-amino-4-methylthiophene-3-carboxylate. 13C NMR (CDCl3) δ 167.5, 166.6, 149.8, 138.1, 134.8, 133.1, 131.4, 113.0, 112.3, 93.2, 51.5, 43.3, 17.8; MH+ 416.0.

Sources & evidence

ORD record
ord-bb2b48de9ee8425589c93989a5fcc7c9
Source dataset
uspto-grants-2015_07
Patent number
US09073891B2

Reaction notes

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