Dichloromethane → 1,1-Dimethylethyl 2-acetyl-2,3-dihydrospiro[isoquinoline-4(1H),4′-piperidine]-1′-carboxylate

HRID 151997Notes

Reaction equation

HRID 151997 reaction equation
[CH3:23][C:24]([Cl:25])=[O:26].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[Cl:34][CH2:35][Cl:36].[N:1]1([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:2][CH2:3][C:4]2([CH2:5][NH:6][CH2:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]32)[CH2:14][CH2:15]1>>[N:1]1([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:2][CH2:3][C:4]2([CH2:5][N:6]([C:24]([CH3:23])=[O:26])[CH2:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]32)[CH2:14][CH2:15]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 46942140tert-Butyl 2,3-dihydro-1H,1'H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate

Product 1

HCID 572265661,1-Dimethylethyl 2-acetyl-2,3-dihydrospiro[isoquinoline-4(1H),4′-piperidine]-1′-carboxylate

Sources & evidence

ORD record
ord-1dea60aa0e5e45b88245e1869c884fbf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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