2-(2-Oxo-1,2,3,4-tetrahydroquinolin-1-yl)acetic acid → 2-(2-Oxo-3,4-dihydroquinolin-1(2H)-yl)-N-(2-(1-trityl-1H-imidazol-4-yl)thiophen-3-yl)acetamide
Reaction equation
[C:1]([N:20]1[CH:24]=[C:23]([C:25]2[S:26][CH:27]=[CH:28][C:29]=2[NH2:30])[N:22]=[CH:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:31]=[C:32]1[CH2:41][CH2:40][C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[N:33]1[CH2:42][C:43](O)=[O:44]>>[O:31]=[C:32]1[CH2:41][CH2:40][C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[N:33]1[CH2:42][C:43]([NH:30][C:29]1[CH:28]=[CH:27][S:26][C:25]=1[C:23]1[N:22]=[CH:21][N:20]([C:1]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:24]=1)=[O:44]Participants
3
Procedure
The title compound was prepared from 2-(1-trityl-1H-imidazol-4-yl)thiophen-3-amine and 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetic acid using protocol B (269 mg, 32%). Method [7] Retention time 9.32 min by HPLC (MH+ 595).
Sources & evidence
- ORD record
- ord-06e9aacfae494738bfd6faff87d66bf6
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09073891B2
Reaction notes
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