Hydrochloric Acid → HCID 67981377, compound

HRID 1520066Notes

Reaction equation

HRID 1520066 reaction equation
[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[C:18]([C:20]4[C:28]5[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][N:30]6[C:35](=[O:36])[CH:34]=[CH:33][CH:32]=[N:31]6)[CH:27]=5)[N:22](C(OC(C)(C)C)=O)[N:21]=4)[N:17]=[N:16]3)=[CH:11][CH:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>O1CCOCC1.CO>[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH:19]=[C:18]([C:20]4[C:28]5[C:23](=[CH:24][CH:25]=[C:26]([CH2:29][N:30]6[C:35](=[O:36])[CH:34]=[CH:33][CH:32]=[N:31]6)[CH:27]=5)[NH:22][N:21]=4)[N:17]=[N:16]3)=[CH:11][CH:10]=2)=[O:8])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67981486HCID 67981486, compound

Product 1

HCID 67981377HCID 67981377, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 3-{1-[4-(morpholin-4-ylcarbonyl)phenyl]-1H-1,2,3-triazol-4-yl}-5-[(6-oxopyridazin-1(6H)-yl)methyl]-1H-indazole-1-carboxylate (202 mg; 0.32 mmol; 1.00 eq.) and HCl (6.00 mL of a 4 N solution in dioxane; 24 mmol; 76 eq.) in MeOH (4 mL) was stirred at RT for 3 h. The reaction mixture was then concentrated under reduced pressure and the residue was purified by preparative HPLC to give the title compound as a white solid. HPLC (Condition A): Rt 2.67 min (purity 98.1%). MS (ESI+): 483.3, MS (ESI−): 481.3.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-747fb49f3be6490e87d50768309dfa9c
Source dataset
uspto-grants-2015_07
Patent number
US09073892B2

Reaction notes

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