Ammonia → HCID 136931791, compound

HRID 1520103Notes

Reaction equation

HRID 1520103 reaction equation
[CH3:1][C:2]1[NH:3][C:4](=[O:13])[CH:5]=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[NH3:14]>CO>[CH3:1][C:2]1[NH:3][C:4](=[O:13])[CH:5]=[C:6]([C:8]([NH2:14])=[O:9])[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 135465814HCID 135465814, compound

Product 1

HCID 136931791HCID 136931791, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve ethyl 2-methyl-6-oxo-1H-pyrimidine-4-carboxylate (7.26 g, 39.9 mmol) in a solution of ammonia in MeOH (70 mL, 7 N) and stir the mixture for 17 hours at ambient temperature. Remove the solvents under reduced pressure to provide the title compound as a black solid (5.7 g, 93.4%). MS (m/z): 154 (M+1).

Workup

  1. customRemove the solvents under reduced pressure

Sources & evidence

ORD record
ord-8ade013e3b83427f80080b892412e3e2
Source dataset
uspto-grants-2015_07
Patent number
US09073901B2

Reaction notes

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