反应详情

To a solution of methyl 3-(6-fluoro-3,4-dihydroquinolin-1(2H)-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (150 mg, 0.43 mmol) in dichloromethane (30 mL) was added pyridine (136 mg, 1.72 mmol) and then Tf2O (243 mg, 0.86 mmol) was added dropwise with stifling at 0° C. The resulting solution was stirred for 4 h at room temperature and then washed with water (3×50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to afford methyl 3-(6-fluoro-3,4-dihydroquinolin-1(2H)-yl)-2-(trifluoromethylsulfonyloxy)quinoxaline-6-carboxylate as red oil (200 mg, crude).

1. customwith stifling at 0° C
2. washwashed with water (3×50 mL)
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated in vacuo