反应详情

To a solution of 7-methoxyquinoline (2.0 g, 12.56 mmol) in methanol (60 ml) was added PtO2 (180 mg, 0.79 mmol). H2 (g) was introduced into above solution and the reaction was stirred overnight at room temperature and then the solids were filtered off. The organics were concentrated in vacuo to give a residue, which was purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether to afford 7-methoxy-1,2,3,4-tetrahydroquinoline as a light yellow oil (1.5 g, 73%).

1. additionH2 (g) was introduced into above solution
2. filtrationthe solids were filtered off
3. concentrationThe organics were concentrated in vacuo
4. customto give a residue, which
5. customwas purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether