反应详情

To a solution of 2-amino-3-methylbenzoic acid (1.23 g, 8.14 mmol, 1.0 eq) in 15 mL of DMSO was added 40% HBr (6.00 mL, 44.7 mmol, 5 eq). The resulting mixture was stirred at room temperature overnight. A white precipitate formed during the course of the reaction. The reaction mixture was quenched with saturated aqueous NaHCO3 resulting in a white solid that was filtered and dried in vacuo to yield 950 mg in 51% yield of Ivi-a as white solid. LCMS m/z=229.9 (M+1) (Method B) (retention time=1.20 min),

1. customA white precipitate formed during the course of the reaction
2. customThe reaction mixture was quenched with saturated aqueous NaHCO3 resulting in a white solid
3. filtrationthat was filtered
4. customdried in vacuo
5. customto yield 950 mg in 51% yield of Ivi-a as white solid