HCID 66900711, compound → HCID 44241236, compound

HRID 1520417Notes

Reaction equation

HRID 1520417 reaction equation
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:33][CH3:34])[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]([CH:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)C(=O)OC(C)(C)C)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1>FC(F)(F)C(O)=O>[CH2:33]([C:13]1[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=[C:2]([NH2:1])[C:11]=2[N:12]=1)[CH3:34]

Participants

3

Reactant 1

HCID 66900711HCID 66900711, compound

Product 1

HCID 44241236HCID 44241236, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl [4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]tetrahydro-2H-pyran-4-ylcarbamate in trifluoroacetic acid was stirred at 40° C. for 4 hrs. Reaction mixture was then poured on ice-water mixture and extracted with chloroform. Organic layer was dried over sodium sulphate and concentrated under deduced pressure to afford the title compound.

Workup

  1. customReaction mixture
  2. additionwas then poured on ice-water mixture
  3. extractionextracted with chloroform
  4. dry with materialOrganic layer was dried over sodium sulphate
  5. concentrationconcentrated under deduced pressure

Sources & evidence

ORD record
ord-a2e3b3e92c9b485fbe41462506721c55
Source dataset
uspto-grants-2015_07
Patent number
US09073913B2

Reaction notes

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