Benzenesulfonyl chloride → HCID 68407000, compound

HRID 1520599Notes

Reaction equation

HRID 1520599 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:7]=[CH:8][C:9]=1[NH:10][CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)([O-:3])=[O:2].[C:21]1([S:27](Cl)(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.C(N(CC)CC)C>C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[C:6]([S:17]([NH2:20])(=[O:18])=[O:19])[CH:7]=[CH:8][C:9]=1[NH:10][CH:11]1[CH2:16][CH2:15][N:14]([S:27]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:29])=[O:28])[CH2:13][CH2:12]1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 433458063-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

Product 1

HCID 68407000HCID 68407000, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of EXAMPLE 157B (84 mg), benzenesulfonyl chloride (46 mg), and triethylamine (101 mg) in CH2Cl2 (2 mL) was stirred for 1 hours. The product was chromatographed on silica gel with 25% ethyl acetate/hexanes.

Workup

  1. customThe product was chromatographed on silica gel with 25% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-d4bdc8a706e34e59a33a432c29f143c3
Source dataset
uspto-grants-2015_07
Patent number
US09073855B2

Reaction notes

Loading…