4-Methoxybenzylamine → 4-methoxycyclohexanemethan amine

HRID 1520639Notes

Reaction equation

HRID 1520639 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1>C(O)C>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([CH2:9][NH2:10])[CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 754524-Methoxybenzylamine

Product 1

HCID 552816864-methoxycyclohexanemethan amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(4-Methoxyphenyl)methanamine (1 g) in ethanol (10 ml) was treated with 5% dry Rh—Al2O3 (0.5 g) under H2 (500 psi) at 60° C. for 6 hours and then at 125° C. for 26 hours. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

Workup

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-ed0f0cf78fa74f8782fda81285946060
Source dataset
uspto-grants-2015_07
Patent number
US09073855B2

Reaction notes

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