Diisopropylethylamine → HCID 67169233, compound

HRID 1520673Notes

Reaction equation

HRID 1520673 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1[NH:22][CH:19]1[CH2:20][CH2:21][N:16]([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 47309215,6-Dichloropyridine-3-sulfonamideHCID 162276441-Cyclopropylpiperidin-4-amine

Product 1

HCID 67169233HCID 67169233, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of EXAMPLE 387A (0.4 g), 1-cyclopropylpiperidin-4-amine (0.3 g) and N,N-diisopropylethylamine (0.37 mL) in dioxane (3 mL) was heated at 100° C. for 18 hours. The crude product was isolated by concentration and was purified on silica gel, which was eluted with ethyl acetate to give the title compound.

Workup

  1. customThe crude product was isolated by concentration
  2. customwas purified on silica gel, which
  3. washwas eluted with ethyl acetate

Sources & evidence

ORD record
ord-d510a31d48bf44608fa052535795a66b
Source dataset
uspto-grants-2015_07
Patent number
US09073855B2

Reaction notes

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