Chlorosuccinimide → HCID 67226591, compound

HRID 1520691Notes

Reaction equation

HRID 1520691 reaction equation
[CH3:1][O:2][C:3](=[O:42])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH2:22][CH2:21][C:20]([CH3:24])([CH3:23])[CH2:19][C:18]=3[C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[CH2:12][CH2:11]2)=[CH:6][C:5]=1[O:32][C:33]1[CH:41]=[CH:40][CH:39]=[C:38]2[C:34]=1[CH:35]=[N:36][NH:37]2.[Cl:43]N1C(=O)CCC1=O>C(#N)C>[NH:37]1[C:38]2[C:34](=[C:33]([O:32][C:5]3[CH:6]=[C:7]([N:10]4[CH2:15][CH2:14][N:13]([CH2:16][C:17]5[CH2:22][CH2:21][C:20]([CH3:24])([CH3:23])[CH2:19][C:18]=5[C:25]5[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=5)[CH2:12][CH2:11]4)[C:8]([Cl:43])=[CH:9][C:4]=3[C:3]([O:2][CH3:1])=[O:42])[CH:41]=[CH:40][CH:39]=2)[CH:35]=[N:36]1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 67144445HCID 67144445, compound

Product 1

HCID 67226591HCID 67226591, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of EXAMPLE 400D (0.5 g) and 1-chloropyrrolidine-2,5-dione (0.126 g) in acetonitrile (10 mL) was stirred at room temperature for 4 hours. The solvent was removed, and the residue was purified by flash column chromatography on silica gel to give the title compound.

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by flash column chromatography on silica gel

Sources & evidence

ORD record
ord-1005fc3ea6cc48b0a1be75e8cea69d79
Source dataset
uspto-grants-2015_07
Patent number
US09073855B2

Reaction notes

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