Cesium carbonate → HCID 60658785, compound

HRID 1520719Notes

Reaction equation

HRID 1520719 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9][CH3:10])=[O:8])[CH2:3][CH2:2]1.Br[C:12]1[S:13][CH:14]=[CH:15][N:16]=1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C)C=O>[S:13]1[CH:14]=[CH:15][N:16]=[C:12]1[N:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9][CH3:10])=[O:8])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 764302-BromothiazoleHCID 424914Methyl isonipecotate

Product 1

HCID 60658785HCID 60658785, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of methyl piperidine-4-carboxylate (2.045 g), 2-bromothiazole (1.64 g), and Cs2CO3 (5.86 g) in N,N-dimethylformamide (15 mL) was heated at 100° C. overnight.

Sources & evidence

ORD record
ord-c536a0dcddf346dfa15124c3f6508f1e
Source dataset
uspto-grants-2015_07
Patent number
US09073855B2

Reaction notes

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