反应详情

温度

60 °C

To a solution of (S)-tert-butyl 2-(4-(5-phenyl-1H-pyrazole-3-carboxamido)phenyl)morpholine-4-carboxylate (120 mg, 268 μmol, Eq: 1.00) in dioxane (0.5 ml) was added 4M-HCl in dioxane (1.00 ml, 4.01 mmol, Eq: 15). The reaction mixture was stirred at 60° C. for 2 h. To the mixture was then added 10 ml of dioxane and the suspension was filtered off, washed with ether and dried under in high vacuum to give the target compound as a white solid (82.3 mg, 79.9%). MS (ISP): 349.2 ([M+H]+).

1. filtrationthe suspension was filtered off
2. washwashed with ether
3. customdried under in high vacuum