反应详情

温度

100 °C

To a stirred solution of 1-[4,5,6-trichloro-1-(2-methoxy-ethoxymethyl)-1H-benzoimidazol-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (0.166 g, 0.372 mmol) and acetic acid (6 mL) was added 6M aq. hydrochloric acid (6 mL). The reaction mixture was heated to 100° C. for 18 h and then cooled to 23° C. The precipitate was collected to yield the titled compound as the HCl salt (0.91 g, 74% yield). MS (ESI/CI): mass calcd. for C11H5Cl3N4O2, 330.0; m/z found, 331.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6): 8.92 (s, 1H), 8.34 (s, 1H), 7.74 (s, 1H).

1. temperaturecooled to 23° C
2. customThe precipitate was collected