反应详情

温度

150 °C

To a stirred solution of 3,5-dibromo-4-methylpyridine (2.0 g, 7.97 mmol) in dry N,N-dimethylformamide (10 mL) was added copper cyanide (1.07 g, 11.95 mmol) at room temperature. The reaction mixture was heated at 150° C. for 6 h, cooled it, quenched with water (5 mL) and extracted with 50% ethyl acetate/hexane (2×100 mL). The combined organic layer was washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated under vacuum to obtain the title compound. MS (M+1): 199.1.

1. temperaturecooled it
2. customquenched with water (5 mL)
3. extractionextracted with 50% ethyl acetate/hexane (2×100 mL)
4. washThe combined organic layer was washed with saturated aqueous sodium chloride solution
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated under vacuum