Tricyclohexylphosphine → HCID 70977491, compound

Participants

Role	Name	HCID	Charge
Reactant	Tricyclohexylphosphine	HCID 75806	—
Reactant	Potassium Acetate	HCID 517044	—
Reactant	Bis(pinacolato)diborane	HCID 2733548	—
Reactant	Methyl 1-(5-bromopyridin-3-yl)cyclopropanecarboxylate	HCID 59578399	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 70977491	HCID 70977491	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a vial containing the title compound from Example 71 Step B (0.150 g, 0.586 mmol), bis(pinacolato)diboron (0.178 g, 0.703 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.054 g, 0.059 mmol), tricyclohexylphosphine (0.033 g, 0.117 mmol) and potassium acetate (0.17 g, 1.76 mmol) was added dioxane (5.9 mL). The reaction was heated to 80° C. for 16 hours. It was then cooled to room temperature, passed through a syringe filter and concentrated under reduced pressure to afford the title compound: LCMS m/z 221.63 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09073929B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-fa6fbae1abb14217b18e3565efe9b0a9
Source note	uspto-grants-2015_07